enCELL series to formulate DDS medicines
The same process conditions can be applied to all the enCELL machines regardless of production volume, which results in minimizing manufacturing cost and time and maximizing profit.
enCELL
Master
enCELL
Pharm
enCELL
Scale-up
enCELL
Mass
Development of Microfluidic
LNP Formulation Machine, enCELL
Award of Korea’s 10 technology breakthrough in mechanical engineering, 2022
GMP
enCELL
Master
This versatile microfluidic platform serves as a cornerstone for researchers, offering precise control over particle generation for a multitude of applications including LNP for mRNA vaccine and therapeutics. From nanoparticle synthesis to bioprocessing, enCELL Master revolutionizes microfluidic particle formulation.
| Size | 400(W) X 500(D) X 600(H) mm |
|---|---|
| Flow rate | 10mL/m |
| Temperature | ~ 50℃ |
Features and Benefits
| Particles | LNP, Liposome, micro/nanoparticles |
|---|---|
| Use | Process optimization and small quantity production |
| Size | 50nm~0.8mm uniform size particles can be manufactured |
| Structure | Particle/emulsion (W/O, O/W, W/O/W, O/W/O) production possible |
| Conditions | Pressure (Flow), Temperature |
| Equipment | 400(W) X 500(D) X 600(H) mm |
| Production | max. 10ml/m |
| Overcome | Solve the problem of expensive sample residue (minimize residue compared to competitors) |
| Advantages | Organic solvents can be used to manufacture various material particles No need for process optimization due to future scale up |
| Price | Equipment KRW 75 million/EA, Cartridge KRW 450,000/Pack |
LNP Formulation Performance of enCELL
- Comparison of Encell mRNA-loaded LNP (lipid nanoparticle) manufacturing performance with leading competitors
- Verification of identical manufacturing performance of particle size, dispersion, dislocation, and encapsulation ratio through crossover and repeat experiments
| LNP Expression | Competitor (Ignite, PNI) |
enParticle 1st (enCELL Master) |
enParticle 2nd (enCELL Master) |
|---|---|---|---|
 |
 |
 |
 |
| Size 9nm) | 84.1±0.2 | 89.5±0.2 | 80.4±0.4 |
| PDI | 0.05 | 0.07 | 0.05 |
| potential (mV) | 16.0±1.6 | 4.5±0.6 | 3.5±1.9 |
Core technology for development of
preclinical/clinical particle production equipment
enCELL
Pharm
Elevating research to clinical scale, enCELL Pharmoperates at a flow rate of 100 mL/min. Designed to meet the stringent demands of pharmaceutical applications, enCELL Pharmproduces uniform particles tailored for targeted therapies and drug delivery systems. With enCELL Pharm, precision and efficiency converge to drive clinical advancements.
| Size | 1350(W) X 750(D) X 2000(H) mm |
|---|---|
| Flow rate | 100mL/m |
| Temperature | Ambient temperature |
Features and Benefits
| Particles | LNP, Liposome, micro/nanoparticles |
|---|---|
| Application | Application to production of pharmaceutical particles for preclinical/clinical use |
| Size | 50nm~0.8mm uniform size particles can be manufactured |
| Structure | Particle/emulsion (W/O, O/W, W/O/W, O/W/O) production possible |
| Conditions | Pressure (Flow), Temperature(option) |
| Equipment | 1350(W) X 750(D) X 2000(H) mm |
| Production | max. 100ml/m |
| Overcome | Solve the problem of expensive sample residue (minimize residue compared to competitors) |
| Advantages | Solving pharmaceutical CMO contamination and cleaning problems using disposable cartridges and consumables Application of manufacturing process technology that does not require optimization to scale up production Equipment operation and particle production costs can be reduced by at least 85% compared to competitors |
| Price | Equipment KRW 550 million/EA, Cartridge KRW 1.75 million/Pack |
Core technology for developing particle production equipment for pilot/mass production
- Application of “Faster, Cheaper, and More” particle production technology
- Significant reduction in production costs and manufacturing time is possible by applying the same optimized process conditions.
enCELL
Scale-Up
enCELL Scale-up produces highly functionalized particles in the wide fields. From pharmaceuticals to cosmetic, enCELL Scale-upprovides microfluidic mass-production services, operating at a flow rate of 5 L/m.
| Size | 1700(W) X 800(D) X 1400(H) mm |
|---|---|
| Flow rate | 5L/m |
| Temperature | Ambient temperature |
enCELL
Mass
Elevating research to clinical scale, enCELL Pharmoperates at a flow rate of 100 mL/min. Designed to meet the stringent demands of pharmaceutical applications, enCELL Pharmproduces uniform particles tailored for targeted therapies and drug delivery systems. With enCELL Pharm, precision and efficiency converge to drive clinical advancements.
| Size | 1350(W) X 750(D) X 2000(H) mm |
|---|---|
| Flow rate | 100mL/m |
| Temperature | Ambient temperature |
Features and Benefits
| Particles | LNP, Liposome, micro/nanoparticles |
|---|---|
| Application | Dedicated to pilot production/mass production pharmaceutical particle CMO production |
| Size | 50nm~0.8mm uniform size particles can be manufactured |
| Conditions | Pressure (Flow), Temperature(option) |
| Equipment | 1700(W) X 800(D) X 1400(H) mm |
| Production | enCELLscale-up max. 550ml/m enCELLmass max. 5L/m |
| Advantages | Cartridge can be reused after cleaning enCELL Master process optimization conditions can be applied to CMO production |
Partner with Us for Microfluidics Excellence
Contact us today to explore how our microfluidics solutions can empower your pharmaceutical endeavors. Let’s shape the future of medicine together.
EnCell is trying to develop a clear and comprehensive sustainability strategy.
This strategy should outline the company's commitment to environmental stewardship, social responsibility, and economic viability. Our company's efforts, setting priorities, and driving continuous improvement towards a more sustainable microfluidics solution company.
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